Agnogenic Myeloid Metaplasia: The occurrence of myeloid tissue in extramedullary sites. Specifically it is a syndrome characterized by splenomegaly, anemia, the presence of nucleated erythrocytes and immature granulocytes in the circulating blood, and extramedullary hemoatopoiesis in the liver and spleen. The primary form is also known as agnogenic myeloid metaplasia, myelosclerosis, and myelofibrosis. The secondary or symptomatic form may be associated with various diseases, including carcinomatosis, tuberculosis, leukemia, and polycythemia vera. (Dorland, 27th ed)

Synonym: myeloid metaplasia, nonleukemic myelosis.

Terms Related to Agnogenic Myeloid Metaplasia

• Extramedullary Myeloid Cell Tumor

  An extramedullary tumor of immature myeloid cells. Granulocytic sarcoma usually occurs with or follows the onset of acute myeloid leukemia (LEUKEMIA, MYELOCYTIC, ACUTE).

• Polycythemia Vera

  A myeloproliferative disorder of unknown etiology, characterized by abnormal proliferation of all hematopoietic bone marrow elements and an absolute increase in red cell mass and ...

• Chloroma

  An extramedullary tumor of immature myeloid cells. Granulocytic sarcoma usually occurs with or follows the onset of acute myeloid leukemia (LEUKEMIA, MYELOCYTIC, ACUTE).

• Myelophthisic Anemia

  Anemia characterized by appearance of immature myeloid and nucleated erythrocytes in the peripheral blood, resulting from infiltration of the bone marrow by foreign or abnormal ...

• Granulocytic Sarcoma

  An extramedullary tumor of immature myeloid cells. Granulocytic sarcoma usually occurs with or follows the onset of acute myeloid leukemia (LEUKEMIA, MYELOCYTIC, ACUTE).

• Myeloid Leukemia

  Form of leukemia characterized by an uncontrolled proliferation of the myeloid lineage and their precursors in the bone marrow and other sites.

• Erythremia

  A myeloproliferative disorder of unknown etiology, characterized by abnormal proliferation of all hematopoietic bone marrow elements and an absolute increase in red cell mass and ...

• Myeloid, Acute, M2 Leukemia

  Progressive, malignant disease of the myeloid tissue in which the granular, polymorphonuclear leukocytes and their precursors predominate.

• Myelogenous Leukemia

  Form of leukemia characterized by an uncontrolled proliferation of the myeloid lineage and their precursors in the bone marrow and other sites.

• Osteopetrosis

  Excessive formation of dense trabecular bone leading to pathological fractures, OSTEITIS, SPLENOMEGALY with infarct, ANEMIA, and extramedullary hemopoiesis (HEMATOPOIESIS, EXTRAMEDULLARY).