A profound state of unconsciousness associated with depressed cerebral activity from which the individual cannot be aroused. Coma generally occurs when there is dysfunction or injury involving both cerebral hemispheres or the brain stem RETICULAR FORMATION.

Proteins transcribed from the E4 region of adenovirus. The E4 19K protein transactivates transcription of the adenovirus E2F protein and complexes with it.

Proteins transcribed from the E3 region of adenovirus but not essential for viral replication. The E3 19K protein mediates adenovirus persistence by reducing the expression of class I major histocompatibility complex antigens on the surface of infected cells.

Proteins transcribed from the E2 region of adenovirus. Several of these are required for viral DNA replication.

Proteins transcribed from the E1B region of adenovirus which are involved in regulation of the levels of early and late gene expression.

Proteins transcribed from the E1A region of adenovirus which are involved in positive regulation of transcription of the early genes.

Cell adhesion molecule and CD antigen that mediates neutrophil, monocyte, and memory T-cell adhesion to cytokine-activated endothelial cells. E-selectin recognizes sialylated carbohydrate groups related to the Lewis X or Lewis A family.

Vaccines or candidate vaccines used to prevent or treat both enterotoxigenic and enteropathogenic Escherichia coli infections.

The period of the history of medicine from 1451 through 1600 A.D. HISTORY OF MEDICINE, 15TH CENT. and HISTORY OF MEDICINE, 16TH CENT. are also available.

A type of MAGNETIC RESONANCE IMAGING that uses only one nuclear spin excitation per image and therefore can obtain images in a fraction of a second rather than the minutes required in traditional MRI techniques. It is used in a variety of medical and scientific applications.