B7-1 Costimulatory Molecule Definition
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B7-1 Costimulatory Molecule:
The natural ligand for the T-cell antigen CD28; (ANTIGENS, CD28); mediating T- and B-cell adhesion. CD80 is expressed on activated B-cells and gamma-interferon-stimulated monocytes. The binding of CD80 to CD28 and CTLA-4 provides a co-stimulatory signal to T-cells and leads to greatly upregulated lymphokine production.Synonym: cd80 antigens, b7 antigen, cd80 antigen, bb 1.