Terms Related to CFTR Mouse

• Cystic Fibrosis Transmembrane Conductance Regulator

  A chloride channel that regulates secretion in many exocrine tissues. Abnormalities in the CFTR gene have been shown to cause cystic fibrosis. (Hum Genet 1994;93(4):364-8)

• SCID-hu Mouse

  Mice homozygous for the mutant autosomal recessive gene "scid" which is located on the centromeric end of chromosome 16. These mice lack mature, functional lymphocytes ...

• mdx Mice

  A strain of mice arising from a spontaneous mutation (mdx) in inbred C57BL mice. This mutation is X chromosome-linked and produces viable homozygous animals that ...

• Quaking Mice

  Mice homozygous for the mutant autosomal recessive gene, quaking (qk), associated with disorder in myelin formation and manifested by axial tremors.

• Athymic Mice

  Mutant mice homozygous for the recessive gene "nude" which fail to develop a thymus. They are useful in tumor studies and studies on immune responses.

• mdx Mouse

  A strain of mice arising from a spontaneous mutation (mdx) in inbred C57BL mice. This mutation is X chromosome-linked and produces viable homozygous animals that ...

• Nude Mice

  Mutant mice homozygous for the recessive gene "nude" which fail to develop a thymus. They are useful in tumor studies and studies on immune responses.