Cytochrome P450 1A2 Definition
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Cytochrome P450 1A2:
A polycyclic aromatic hydrocarbon-inducible cytochrome which is of significant clinical interest due to the large number of drug interactions associated with induction and inhibition of theophylline. Caffeine is considered to be a model substrate for this enzyme. It also metabolizes theophylline and antipyrene. Environmental factors including cigarette smoking, charbroiled meat, cruciferous vegetables, and a number of drugs including phenytoin, phenobarbital, and omeprazole produce increases in CYP1A2 activity. (Ann Pharmacother 1995;29:619-24) EC 1.-.Synonym: cytochrome p 450d, cytochrome p 450 lm4, cytochrome p 450 cyp1a2, cyp 1a2, caffeine demethylase, phenacetin o dealkylase.