GABA-A Receptor Definition


GABA-A Receptor: Cell surface proteins which bind GAMMA-AMINOBUTYRIC ACID and control an integral membrane chloride channel. GABA-A receptors are the most prevalent inhibitory neurotransmitter receptors in the brain. Several isoforms have been cloned, and they belong to a superfamily which includes nicotinic receptors, glycine receptors, and 5HT-3 receptors. Most GABA-A receptors have separate modulatory sites sensitive to benzodiazepines and to barbiturates.

Synonym: gaba(a) receptor, gaba benzodiazepine receptor, diazepam receptor, benzodiazepine receptor, benzodiazepine gaba receptor, muscimol receptor.