MACs (Chromosomes) Definition

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MACs (Chromosomes):

DNA constructs that are composed of, at least, all elements, such as a REPLICATION ORIGIN; TELOMERE; and CENTROMERE, that are required for successful replication, propagation to and maintainance in progeny mammalian cells. In addition, they are constructed to carry other sequences for analysis or gene transfer.

Synonym: mammalian artificial chromosome, mac (chromosome), artificial, mammalian chromosomes.

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