Terms Related to Nonsense Mutation

• Stop Codon

  Any codon that signals the termination of genetic translation (TRANSLATION, GENETIC). PEPTIDE TERMINATION FACTORS bind to the stop codon and trigger the hydrolysis of the ...

• Codon

  A set of three nucleotides in a protein coding sequence that specifies individual amino acids or a termination signal (CODON, TERMINATOR). Most codons are universal, ...

• Start Codon

  A codon that directs initiation of protein translation (TRANSLATION, GENETIC) by stimulating the binding of initiator tRNA (RNA, TRANSFER, MET). In prokaryotes, the codons AUG ...

• Genetic Code

  The specifications for how information, stored in nucleic acid sequence (BASE SEQUENCE), is translated into protein sequence (AMINO ACID SEQUENCE). The start, stop, and order ...

• Missense Mutation

  A mutation in which a codon is mutated to one directing the incorporation of a different amino acid. This substitution may result in an inactive ...

• tRNA(Met)

  A transfer RNA which is specific for carrying methionine to sites on the ribosomes. During initiation of protein synthesis, tRNA(f)Met in prokaryotic cells and tRNA(i)Met ...

• Translation Polarity

  Decrease in the synthesis of proteins specified by genes distal to the operator and to the site of a nonsense, frameshift, deletion or insertion mutation ...