UML-491 Definition

UML-491: An ergot derivative that is a congener of LYSERGIC ACID DIETHYLAMIDE. It antagonizes the effects of serotonin in blood vessels and gastrointestinal smooth muscle, but has few of the properties of other ergot alkaloids. Methysergide is used prophylactically in migraine and other vascular headaches and to antagonize serotonin in the carcinoid syndrome.

Terms Related to UML-491

Lysergic Acid Diethylamide
Semisynthetic derivative of ergot (Claviceps purpurea). It has complex effects on serotonergic systems including antagonism at some peripheral serotonin receptors, both agonist and antagonist actions ...
Ergotrate
An ergot alkaloid (ERGOT ALKALOIDS) with uterine and vascular smooth muscle contractile properties.
LSD 25
Semisynthetic derivative of ergot (Claviceps purpurea). It has complex effects on serotonergic systems including antagonism at some peripheral serotonin receptors, both agonist and antagonist actions ...
Ergot Alkaloids
Alkaloids originally isolated from the ergot fungus Claviceps purpurea (Hypocreaceae). They include compounds that are structurally related to ergoline (ERGOLINES) and ERGOTAMINE (ERGOTAMINES). Many of ...
Malignant Carcinoid Syndrome
A symptom complex associated with CARCINOID TUMOR and characterized by attacks of severe flushing of the skin, diarrheal watery stools, bronchoconstriction, sudden drops in blood ...
BC-105
Serotonin antagonist used against migraine and vascular headaches.
Serotonin Agonist
Agents that have an affinity for serotonin receptors and are able to mimic the effects of serotonin by stimulating the physiologic activity at the cell ...

Synonym: methysergide maleate, methysergide dimaleate, methysergide, methylmethylergonovine, dimethylergometrin, desril, deseril, sansert.