Choleragen Definition


Choleragen: The enterotoxin from Vibrio cholerae. It is a protein that consists of two major components, the heavy (H) or A peptide and the light (L) or B peptide or choleragenoid. The B peptide anchors the protein to intestinal epithelial cells, while the A peptide, enters the cytoplasm, and activates adenylate cyclase, and production of cAMP. Increased levels of cAMP are thought to modulate release of fluid and electrolytes from intestinal crypt cells.

Synonym: vibrio cholera cytotoxin v, choleragenoid, cholera toxin protomer a, cholera toxin b subunit, cholera toxin, cholera exotoxin, procholeragenoid.

Additional tags: what is choleragen