Choleragen Definition
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Choleragen: The enterotoxin from Vibrio cholerae. It is a protein that consists of two major components, the heavy (H) or A peptide and the light (L) or B peptide or choleragenoid. The B peptide anchors the protein to intestinal epithelial cells, while the A peptide, enters the cytoplasm, and activates adenylate cyclase, and production of cAMP. Increased levels of cAMP are thought to modulate release of fluid and electrolytes from intestinal crypt cells.
Synonym: vibrio cholera cytotoxin v, choleragenoid, cholera toxin protomer a, cholera toxin b subunit, cholera toxin, cholera exotoxin, procholeragenoid.
Additional tags: what is choleragen