HMSN I Definition
HMSN I: A hereditary motor and sensory neuropathy transmitted most often as an autosomal dominant trait and characterized by progressive distal wasting and loss of reflexes in the muscles of the legs (and occasionally involving the arms). Onset is usually in the second to fourth decade of life. This condition has been divided into two subtypes, hereditary motor and sensory neuropathy (HMSN) types I and II. HMSN I is associated with abnormal nerve conduction velocities and nerve hypertrophy, features not seen in HMSN II. (Adams et al., Principles of Neurology, 6th ed, p1343)
Synonym: peroneal muscular atrophy, muscular, peroneal atrophy, type ii charcot marie tooth disease, type ib charcot marie tooth disease, type ia charcot marie tooth disease, type i charcot marie tooth disease, hmsn type is, hmsn type ii, hmsn type i, hmsn is, hmsn ii, hmn distal type i, hereditary type i motor and sensory neuropathy, hereditary motor and sensory-neuropathy type ii, charcot marie tooth disease, charcot marie disease, and sensory neuropathy type i hereditary motor, type ii hereditary motor and sensory neuropathy, type i hereditary motor and sensory neuropathy, roussy-levy syndrome, hmsn type iis.