Hypertrophic Motor Sensory Neuropathy Spastic Paraplegia Definition


Hypertrophic Motor Sensory Neuropathy Spastic Paraplegia: A group of inherited diseases that share similar phenotypes but are genetically diverse. Different genetic loci for autosomal recessive, autosomal dominant, and x-linked forms of hereditary spastic paraplegia have been identified. Clinically, patients present with slowly progessive distal limb weakness and lower extremity spasticity. Peripheral sensory neurons may be affected in the later stages of the disease. (J Neurol Neurosurg Psychiatry 1998 Jan;64(1):61-6; Curr Opin Neurol 1997 Aug;10(4):313-8)

Synonym: hereditary autosomal recessive spastic paraplegia, autosomal recessive hereditary spastic paraplegia, autosomal dominant spastic paraplegia hereditary, autosomal dominant hereditary spastic paraplegia, spastic paraplegia, x-linked recessive hereditary, spastic paraplegia, autosomal dominant hereditary, hmsn vs (hereditary motor and sensory neuropathy type v), hmsn v (hereditary motor and sensory neuropathy type v), hmsn type v, hereditary x linked recessive spastic paraplegia, hereditary spastic paraplegia, hereditary motor sensory neuropathy with pyramidal signs, hereditary autosomal dominant spastic paraplegia, x-linked recessive, hereditary spastic paraplegia, type v hereditary motor and sensory neuropathy, spastic, hereditary paraplegia, spastic paraplegia-hypertrophic motor-sensory neuropathy, hmsn (hereditary motor and sensory neuropathy type v) vs.