Rb Gene Definition in Medical Conditions Dictionary

Rb Gene:

Tumor suppressor genes located on human chromosome 13 in the region 13q14 and coding for a family of phosphoproteins with molecular weights ranging from 104 kDa to 115 kDa. One copy of the wild-type Rb gene is necessary for normal retinal development. Loss or inactivation of both alleles at this locus results in retinoblastoma.

Terms Related to Rb Gene

BRCA1 Gene
A tumor suppressor gene (GENES, SUPPRESSOR, TUMOR) located on human chromosome 17 at locus 17q21. Mutations of this gene are associated with the formation of ...
Allelic Loss
The loss of one allele at a specific locus, caused by a deletion mutation; or loss of a chromosome from a chromosome pair. It is ...
BRCA2 Gene
A tumor suppressor gene (GENES, SUPPRESSOR, TUMOR) located on human chromosome 13 at locus 13q12.3. Mutations in this gene predispose humans to breast and ovarian ...
LOH
The loss of one allele at a specific locus, caused by a deletion mutation; or loss of a chromosome from a chromosome pair. It is ...
p53 Gene
Tumor suppressor genes located on the short arm of human chromosome 17 and coding for the phosphoprotein p53.

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Medical Conditions Dictionary

Rb Gene Definition

Terms Related to Rb Gene

BRCA1 Gene

Allelic Loss

BRCA2 Gene

LOH

p53 Gene

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