Second Cancer Definition


Second Cancer: Abnormal growths of tissue that follow a previous neoplasm but are not metastases of the latter. The second neoplasm may have the same or different histological type and can occur in the same or different organs as the previous neoplasm but in all cases arises from an independent oncogenic event. The development of the second neoplasm may or may not be related to the treatment for the previous neoplasm since genetic risk or predisposing factors may actually be the cause.

Synonym: treatment-related cancer, treatment-associated cancer, therapy-related cancer, therapy-associated cancer, second primary cancer, second malignancy, metachronous second primary neoplasms, metachronous neoplasm, treatment-related neoplasm, treatment-associated neoplasm, treatment related neoplasms, treatment associated neoplasms, therapy-related neoplasm, therapy-associated neoplasm, therapy related neoplasms, therapy associated neoplasms, second primary neoplasm, second neoplasm.