Tissel: An autologous or commercial tissue adhesive containing fibrinogen and thrombin. The commercial product is a two component system from human plasma that contains more than fibrinogen and thrombin. The first component contains highly concentrated fibrinogen, Factor VIII, fibronectin, and traces of other plasma proteins. The second component contains thrombin, calcium chloride, and antifibrinolytic agents such as aprotinin. Mixing of the two components promotes clotting and the formation and cross-linking of fibrin. The tissue adhesive is used for tissue sealing, hemostasis, and wound healing.

Synonym: fibrinogen adhesive, fibrin tissue adhesive, fibrin adhesive, autologous fibrin tissue adhesive, fibrin sealant system, fibrin sealant, fibrin seal, fibrin klebe system immuno, fibrin glue, beriplast, transglutine, tissucol, tisseel.

Terms Related to Tissel

• Thrombin Time

  Test of the conversion of fibrinogen to fibrin by thrombin in which clotting time of plasma mixed with a thrombin solution is measured. Time is ...

• Fibrinogen

  Plasma glycoprotein clotted by thrombin, composed of a dimer of three non-identical pairs of polypeptide chains (alpha, beta, gamma) held together by disulfide bonds. Fibrinogen ...

• Abnormal Fibrinogens

  Fibrinogens which have a functional defect as the result of one or more amino acid substitutions in the amino acid sequence of normal fibrinogen. Abnormalities ...

• Fibrinopeptides A

  Two small peptide chains removed from the N-terminal segment of the alpha chains of fibrinogen by the action of thrombin during the blood coagulation process. ...

• Fibrin Foam

  A dry artificial sterile sponge of fibrin prepared by clotting with thrombin a foam or solution of fibrinogen. It is used in conjunction with thrombin ...

• Fibrinopeptide A

  Two small peptide chains removed from the N-terminal segment of the alpha chains of fibrinogen by the action of thrombin during the blood coagulation process. ...

• Fibrospum

  A dry artificial sterile sponge of fibrin prepared by clotting with thrombin a foam or solution of fibrinogen. It is used in conjunction with thrombin ...

• Defibrol

  A proteolytic enzyme obtained from the venom of fer-de-lance (Bothrops atrox). It is used as a plasma clotting agent for fibrinogen and for the detection ...

• Thrombin Receptor

  Cell surface proteins that specifically bind thrombin and trigger changes in the behavior of blood cells. There are at least two types of thrombin receptors ...

• Hemocoagulase

  A proteolytic enzyme obtained from the venom of fer-de-lance (Bothrops atrox). It is used as a plasma clotting agent for fibrinogen and for the detection ...